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In the last 25 years leech therapy has made a comeback in the area of microsurgery and reimplantation sur­gery. Leeches (Hirudo medicinalis) can secrete several biologically active substances including fibrinase, proteinase inhibitors, and hirudin, an anticoagulant, useful in postoperative care of skin grafts and reimplanted fingers, ears, and toes.

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